The pipes go to the sides of the spare and between the shackles for the leaf springs. No problems fitting on most cat back systems. The only time you can run into problems is putting something bigger than 2.5" pipes out the back b/c there is not enough room for pipes and spare tire. However that Gibson Exhaust that you have posted has 1.75" tailpipes which are tad small, but would easily fit. I would try to go with at least 2.25 for a better sound. I have 2.5" pipe all the way from the cats to the muffler then out the back and I love the sound and volume it gives off.
-2011 F-150 Lariat: 5.0 "Coyote" V8, 6-spd Auto (6R80E), 3.73 ELocker. White Platinum Metallic Tri-coat.
-1992 Ford Ranger: 4.0L OHV, 5spd (M5OD-R1), 3.27 Open.