To me, it sounds like it would be just like a Manual Hub left in the locked position permanently. And I did that every winter after I got my AVM Hubs on the 99. From November to April, I never unlocked the hubs and didn't really have a problem.
Worst that can happen is you blow one up when driving on pavement and if it's just an extra set anyway, no worries.
Granted, if it's just a pavement pounder most of the time I don't see a reason to do it. Would only really help you if you were having issues with the Hubs not activating in 4wd (i.e. you'd need to have a reason to be in 4wd).
1999 Ranger XLT -- "Project Unknown"
2010 Subaru Impreza -- "The Daily"