Pretty much every state or province requires a vehicle to undergo a technical inspection before the new owner can register it. From there, I think you can only register a vehicle for up to 2 years before you need to renew the registration stickers.
I just had my truck inspected in Ontario and it passed, and 2 weeks ;ater I moved to Alberta, and I needed another inspection done before I could register it here in Alberta, and I had to pay for 1 year registration, but I get to send my old Ontario plates back home and I get a refund on the remaining time for my registration sticker.
Once you own the vehicle and the inspection is completed and the vehicle is then plated, your only responsibility is to renew the plate sticker when it is due. Most places only require a vehicle to be inspected when it changes owners.