You are asking a ridiculously vague question. You need to provide a lot more information if you want opinions on a good setup.
There are a million rim/tire setups, literally. You aren't going to loose any advantages of owning a truck with a different rim/tire setup unless you go low profile. Low profile will reduce offroading capabilities.
What do you want simon? We can't tell you. Are you going to lower the truck, lift the truck? If so how much? What do you use your truck for? Your tire choices will drastically change due to ride height.
Ask specific questions. I can't give you a rim/tire choice so you have a "dam nice minitruck but don't lose advantages of having a truck"
Mods-32 BFG K02s, SCT 91 Tune, Flowmaster Exhaust, 4.10 Ford Racing Gears, Tinted Windows, Tonneau Cover, Kenwood Headunit, Infinity Kappa Speakers, 12 in Alpine Type-R sub, 4x50w and 1x600w Alpine Amps, Signal Mirror Kit, Custom Painted Interior, HIDs, 2 150w KC 6" lights, Mustang Dome Light