Wheel spacers/adapters are sometimes a necessary evil -- and they can be a problem.
Your post is right on.
A big factor I would also weigh in is the offset of your wheels. If they are stockers and you move them out an inch it will be similar backspacing to most after market wheels, (MT classics) and similar stresses. Which usually isn't disastrous.
After some research I decided to give them a try a little over a year ago because the fiberglass made the 12.5s look tucked. I ran them on all corners for about a year. The wider track up front looked cool but made the truck wander around on the road and gave some bumpsteer. Eventually I traded them for wider tires.
As people said if you get them tighten them down gradually to make sure they center on the lugs. I measured the factory studs around 1.25" long, but have read if you get under 1.5" spacers you will have to trim the studs.