The code that I am currently experiencing is P0352, pointing towards a faulty ignition coil specifying cylinder number two. I bought and installed a new ignition coil pack and new spark plugs but that did not fix my problem. I cleared codes after replacing cool but it's still acting up. It Will vibrate in neutral after starting the ignition and acceleration is extremely slow.
Any suggestions?
Note: this has been a problem that has gradually gotten worse. At first if I turn the truck back off and back on and it would work with no problems, but now it vibrates immediately upon ignition. Sometimes I could be driving and all of a sudden it felt like the transmission slips and then the truck would go into this weird mode like a "limp mode". Acceleration would be very slow and a lack of shifting up and gears. Sometimes I could turn the truck off and back on and it would function perfectly fine. Very confused. Any input would help thanks

 

Welcome to the forum

I assume a Ford Ranger, and in this section a 2.9l or 3.0l engine
Coil pack reference means 3.0l engine, because 2.9l only used distributor
So assume 1995 or up Ranger with 3.0l
And automatic trans from the slipping comment

But thats as far as I can go without the year of the vehicle

P0352 is most likely a computer(PCM) problem, you can read here: https://www.ranger-forums.com/2-9l-3.../p0352-140942/

The PCM grounds the coils in the pack then ungrounds each coil to send out the spark, same as old "points" system did.
There were a few years of Ford PCMs that did have failures in the transistors that did the grounding and ungrounding.

And the fact turning PCM OFF and back ON changed engine operation would also point to PCM issue

Year of the Ranger would be helpful

 

I am sorry for not specifying!! Yes you are correct, it is a 2004 Ford Ranger 3.0L. Thank you for the response!!
What about a possible vacuum leak?
Thanks again

 

Vacuum leak is unlikely with your symptoms, and code number

Vacuum leak causes high idle after warm up and often Lean Codes

May be worth a call to Ford dealer, give them your VIN and see if your vehicle has any TSB's(Technical Service Bulletins) regarding spark system

2004 to 2006 3.0l Rangers did have the recessed Exhaust valve seat issue, both heads needed to be replaced.
Same symptoms you have but...........you always get Misfire codes, P0301-P0306 and/or P0316

P0352 is circuit between Coil Pack and PCM, "B" coil in the pack

Coil pack for a V6 has 3 coils inside, A, B and C, each coil sparks TWO spark plugs
Codes are:
P0351 Ignition Coil A Primary/Secondary Circuit Malfunction
P0352 Ignition Coil B Primary/Secondary Circuit Malfunction
P0353 Ignition Coil C Primary/Secondary Circuit Malfunction

When PCM unGrounds Coil B it should get a feedback pulse at that time AND when it Grounds the B coil again, it's not so sets that P0352 code
Yes, could be the coil, but you changed that

It could be the "B" coil wire from PCM to coil has failed, long shot but not "no shot",
In 2004 your PCM connector should be in engine bay upper center of firewall off to passenger side, big long connector lots of wires
Water can get into these at that location.
Disconnect battery
Pull off the bolt holding connector to PCM
Pull off the connector
Check for water or corrosion

Coil pack will have 4 wires, one will be Red, that the 12volts, not hooked to PCM
The other 3 wires will be Tan, but each will have a different colored stripe on it
1. Tan/white stripe, 26
2. Tan/green stripe, 78
3. Tan/orange stripe, 52

The numbers are the pin numbers on the PCM connector
Here is the pin numbering on the connector side: http://mechdb.com/images/0/0e/Ford_EEC5_pinout.png

You will see pins 26, 52, and 78 are at the one end
You need to use an OHM meter and test Coil Pack end of each wire to its PCM pin wire
If wires test OK then..............

Best guess is that it will be a PCM problem, but it is still a guess, no crystal ball here :)