As far as tips in tricks, the only specialty tool you need is a fuel line disconnect tool. This will be needed if the rails come off, probably not necessary if you're swapping injectors. It's a plastic tee shaped tube about 1" long. The parts store carry them in a package with several sizes. Let me specify this was the case on my 2003 model year. Not sure how far back (model year) this tool is needed.
If you need to do this in a day, hope that someone like Rogue has them in stock. You can buy them rebuilt then send your old ones back for a core refund. I just did my 2002 with the flex fuel injectors. The truck had to sit for a while waiting to get them rebuilt. Thats the price of oddball parts. Flex fuel injectors are fairly rare. No choice but to wait or spend several hundred for a new set.